Bidirectional signaling between EGFR and ER contributes to pathophysiology.

2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Bidirectional signaling between EGFR and ER contributes to pathophysiology.

"Interactions between the estrogen receptor (ER) and the epidermal growth factor receptor (EGFR) contribute to the biological effects of these binding protein families," scientists in the United States report.

"EGFR stimulates DNA synthesis and gene transcription in the uterus, related in part to estrogen-independent activation of the nuclear ER. This results from signal transduction enacted by the plasma membrane tyrosine kinase growth factor receptor, leading to 1) phosphorylation and activation of the nuclear ER, and 2) phosphorylation of …